Unfortunately, only one out of three healthcare associated infections can be prevented, even if all preventive measures are applied by the book. Hospitals are indeed crowded with people that are very receptive to infections: weakened elderly people, patients with a strongly challenged immune system (e.g. patients having had an organ transplantation or chemotherapy) and patients needing far-going treatments for life threatening diseases (e.g. patients on intensive care or neonatal departments). However, we have to do all we can to avoid healthcare associated infections as much as possible. Hand hygiene is one of the most effective ways to do so.